Pan-European and Supra-National EQ-5D value sets

Within Europe, country-specific value sets for the EQ-5D instruments are increasingly being utilized for economic evaluations. These national value sets are a helpful tool for international economic evaluations as more countries are initiating partnerships to enhance the access of patients to high quality and cost-effective treatments throughout Europe. In the absence of a national value set, investigators tend to use a value set from other countries as a proxy of the national-specific value set. To address the issue of the lack of value sets in some countries and explore the heterogeneity that might stem from cultural and contextual factors, ‘Pan-European’ and ‘Supra-National’ value sets were developed by combining the existing value sets from different countries in Europe.

The Pan-European and Supra-National value sets combine utilities from valuation studies, using Time Trade-Off (TTO) techniques in the case of the EQ-5D-3L and the EQ-VT protocol for the EQ-5D-5L, from different European countries to provide means for standardizing multi-country economic evaluations. In our analysis, the linear regression model comprised both the Pan-European and Supra-National value sets. Potential use of these value sets may help diminish country-specific differences in cost-effectiveness analyses from individual countries. The EQ-5D-3L Pan-European and Supra-National value sets were created from the existing national value sets from twelve European countries (availability as of December 2022): Denmark, France, Germany, Hungary, Italy, the Netherlands, Poland, Portugal, Romania, Slovenia, Spain and United Kingdom. The EQ-5D-5L Supra-National value sets included national value sets from ten countries: Denmark, France, Germany, Hungary, Ireland, Italy, the Netherlands, Poland, Portugal and Spain.

National value sets

All value sets are available in the open access publications and their use is conditional upon the citation of the references below.


Sajjad A, Versteegh MM, Santi I, Busschbach J, Simon J, Hakkaart-van Roijen L. In search of a ‘pan-European value set’; application for EQ-5D-3L. BMC Medical Res Methodol. 2023;23(13). DOI: 10.1186/s12874-022-01830-3

Łaszewska A, Sajjad A, Busschbach J, Simon J, Hakkaart-van Roijen L. Conceptual Framework for Optimised Proxy Value Set Selection Through Supra-National Value Set Development for the EQ-5D Instruments. PharmacoEconomics. 2022;40: 1221-1234. DOI: 10.1007/s40273-022-01194-y